I was looking at the SCAT web site and the 6" rod has a pin end dia of 0.927". The stock LS1 rod is 0.943" dia. I don't think that combination will work. All stock LS1 pistons I looked at do not have a 0.927 pin dia. All have 0.942" ins dia. I thought why not use the whole LS1 rod/piston combination. Looking further I found Lunati makes a rod bearing set (PN CR867HP) that will space a 2.10" rod to fit the 2.00" small journal. Also the LS1 rod is 6.098" long and the 4.8 lit LS rod is 6.278" long due to the shorter stroke. If the longer rod is used would it address T Lowes comment about the piston being lower in the block. This is a paper investigation as I have no real hardware to see if this is feasible. I find this approach very interesting. Any thoughts appreciated on this.
The wrist pin issue can easily be corrected by honing the rods S/E to fit the LS pins. In a perfect world, the pistons would work out to give you a near zero deck, but when you try to swap non-standard components around, you may have to cut and trim parts to make it work to suit your needs better. But then again, this is a budget rod and piston swap that will cost about the same for a set of H-beam rods and pistons together as just a set of forged pistons for the 250 by themself.
Using the LS specific rod and piston will require you to cut the piston top because it will stick up out of the block and also require a spacer bearing for the rod journals, plus they are already too narrow for the 250 crankshaft.