It may I don't know, as I've only used them on the 292 engine.
I would think the Muffler Shop could "give her a bend or two".
Unless your building a "really hot" 250 engine, just use the stock one, as the only difference in at 'high' RPM. The "really hot" ones use headers to get even more etc.
Good luck.
John M., I.I. #3370
"There are no shortcuts to any place worth going". -Anon