Because of not knowing your driving style, weight of your vehicle, or the aerodynamics involved, it'd be difficult to predict your mileage. However, a while back, a friend had a mildly modified 292/ 3-speed OD with a 3:73 rear end, in a '50 chevy 1/2 ton pickup. He was averaging about 17 mpg on the road. When he badly over-reved it one time, it threw a rod. Then, he replaced the 292 with with a 250, using the same intake and headers, transmission and rear end. His mileage went to about 20 mpg on the road, but he didn't have the low-end torque as before. My stock '65 Chevy pickup with a 250 would get about 17 mpg, on the road, with the standard 3-speed tranny. Don't remember what rear gears I had, though. Maybe this will give you a ball-park figure.