When you buy thecam you can have them drill &tap the center. Now if your talking about drilling and tapping it where the gear & cam mate yes you could do it with a hand drill. BUT it would be much safer to do on a drill press and You would also be sure the Hole Is in true alignment(square,level) how ever you want to look at it.
If the end of the cam is or has been drilled You will need a specail washer & bolt.Plus the timing cover will need a small mod to clear the bolt&washer. If you drill the matting edge you can just use a 1/4inch alen screw.