I am not very familar with the big Holley two barrel, but I believe it is basically half of a Dominator. I would think it would be difficult to tune for a small street motor as it is not a progressive carb. Both barrels would be getting fuel at the same time.
The local circle track use them on ~260 cube inlines as they are restricted to a two barrel on a stock manifold. Of course these are light weight cars and are usually either flat out or off and driveability is not an issue.
