I don't see why not. The Holley computer should pickup the RPM signal as 3/4 of the actual RPM. This should cut the amount of fuel down about right for two less cylinders??? I saw a guy a few years ago who had one on a six in a Jeep. He said it worked well. He also said that when he contacted Holley about the possibility of this application that Holley got really snotty with him and informed him they were for V8s only. Joe