Yes, the 4x4 S10 has been used by many.
Most aftermarket rims are available with a variety of backsets, so you should be looking at rims at the same time you are contemplating your rearend width so you don't end up buying sometyhing twice...
You should have at least 1" of clearance on the inside as well, or it will rub going around corners.
Gearing selection should be somewhere between 2.73 and 4.11 depending on engine/tranny combo and application. Any Chevy parts counter should be able to give you specifics.
The aftemarket also offers a wide selection of gear sets for this rearend.
