a 49-54 chevy rear is about 59-60" wide. i have an s10 4wd rear end under my 50 chevy coupe. the s10 4wd rear end is exactly 3/4" narrower than the 50 chevy rear, wheel bolt surface to wheel bolt surface. truth is if you have the fabrication skills & the inclination you can make anything fit. but for practical purposes ( & decent tire & wheel size ) the s10 2wd rear end is too narrow for a 49-54 chevy.
as far as what year model, well that doesn't make alot of difference as all the s10 rear ends were the same during all years with the exception of some of the last blazers which had disc brakes & some of the last 4.3 v6 trucks which had an 8.5" ring gear & was a different axle all together.
robert


inliner # 3850