Brad, unless you want to be buying a new block, better stay with a .060 overbore and 307 pistons. The 250 is a "thin wall" casting and .125 over is living dangerously . Unless you have major $$ to spend, just clean up the head with a good 4 angle vavle job and 1.94 intakes. Cam selection depends on gearing, stick vs. auto tranny etc. Clifford or Stovebolt Engine Co can best advise you on this.