The concerns for supercharging any engine are basically the same. There are plenty of books out there on how to do it properly. Like Ed said, the oiling system would be my concern. Whether babbitted or insert I don't think would matter as they are made from the same material, but the rods on a 216 may be too weak. Also, better pistons would be needed. The 37-47 216's actually used iron slugs instead of aluminum. Keeping the boost low and not abusing it would help, but then what would be the point of doing it other than to say "because I can". Not that there's anything wrong with that, it's one of the basic tenets of hot rodding, I guess.
