I'm running a 500 Edelbrock on my 250 using an Offy manifold. The carb is sideways with the primaries inboard toward the head. I had to use a 1/2" thick 4 hole spacer to raise the carb enough so the throttle linkage would clear the manifold. I am using a Lokar throttle cable with a nice gentle bend around the outside of the carb to the throttle arm. The brackets to mount and support the cable I had to make and actually used the original Chevy 6 cylinder bellcranks that were on the intake manifold. A little cutting and redrilling, a little welding, a little black paint and they did the job. These newly refabbed brackets now mount on the carb flanges under the stud nuts.
As for how or why the carb sits sideways all I can say is like Jack mentioned - other Inliners claimed thats the way it ought to be and after thinking about it it made sense as far as semi even fuel distribution instead of the primaries appearing to favor the front 3 cylinders. Whether or not it really matters I can't say; but from my experience with now over 9000 miles on the engine I can tell you it runs perfectly around town, on the highway for 13 hours at a time, and for the occaisional stop light drags when it kicks V8 butt. It's not broke so I have no intention of fixing it.
Mike
37 Chevy, 250 / Muncie 4 speed