6 injectors at 42lbs?!? Jeez. That puts you at about enough capacity for ( (6*42)/0.55 ) 460 HP! Not so bad at all! Better to be too rich that too lean. Ed, I'm not sure what you're aiming for in the sense of power but even if you only had 3 of those size of injectors (42lbs) you'd probably still be good to about 230HP. Not sure about how well that would work (large port, weird flow, single injector.....might not be nice at idle). As far as throttle body it kinda depends what you're running as engine control. Megasquirt will run anything with a linear TPS is I remember right (might wanna double check). So it'll run different makes too. If you're just in the planning phase of EFI it might be useful to look into throttle body injection. Often those conversions are a lot easier and let you get started with EFI tuning ideas and such.

I'm using two throttle bodies because I figure I can get better air distribution that way. They're setup so that each runner can draw from each throttle body (but they're not evenly spaced between the runners) so the distribution should be pretty good. We're going to see I guess. I've made enough design assumptions I can't be sure how it'll all work until I actually try it. I figure I can't really make it worse than the stock manifold (although I'm not really sure just how good it is).