samwise: i suppose the deciding factor would be ease of installation...2x1 would need a bit of work to setup and get linkages setup as well as tuning them in sync...the single 2BBL carb would pretty much be a quick bolt on, maybe modding up the throttle linkage...i think that the 2x1 would be the best way for performance and efficiency cause with the carb in the middle the end chambers get a leaner mixture of gas...if u run 2 carbs and set them up at the 2nd and 5th intake then u will get an even mixture between all the cylinders..hope this helps u decide....
Ron: u will be fine using the round tubing ( i'm guessing around 2 1/2"??) weld them outside, but if u want and can clean it up nice on the inside, do both cause that'll just mean its stronger...the 2 that are close together may be a bugger to weld with a mig welder, but a stick should get in there fairly easy...just as long as there's no exhaust leak u should be fine...