From Allpar page talking about testing the hemi head on a Chrysler 6.
 Quote:
A double overhead camshaft arrangement driven by a dual chain had to be made to accommodate the Hemi shaped combustion chamber. Once that was done, and suitable modifications made to the Chrysler 6 cylinder engine, it was installed in a Chrysler car. The test vehicle went to Wallace Zierer, who was in charge of getting results in actual road test conditions.

Mr. Zierer reported significant power increases. The engine ran easily on the 80 octane fuel that was standard for the time. Roughness, which was the current theory about hemispherical heads, just did not exist under any condition. The Hemi head 6 cylinder engine actually being smoother than the flathead 6 cylinder, with a nearly undetectable level of noise and vibration at idle speeds.
I would sure like to know what those 'suitable modifications' were.