John, If we are talking about Chrysler flathead sixes, you can do that. One of the first projects the boss gave me when I started work in a gas station in 64, was to put a 59 six in a 38 pickup. The 38 came off a Diary farm in Gilroy. There were places were I had to dig in 3-4 inches of caked on mud to get to the bolt. There weren't any complications at all that I can remember.
Larry