I may have a different view on this than most of the guys on this board. If you want a good daily driver I would basically do a stock rebuild on the 250, maybe .030 over, but have a good balance job done. Put on a good harmonic damper (Fluidamper seems to be a good brand, keep the stock manifold and 1 barrel(but rebuild it and add a manual choke), get a set of Tom Langdon's cast headers, a floor shift, and drive it! Don't forget a good distributor! Keep the stock trans and rear gear, especially if it's a 3.55 or 3.70. I actually drove an older version of this for about 6 years. I had a '40 Chevy coupe I rebuilt a 235 for. It was .060 over with Jahns pop-up pistons, the mildest McGurk cam, Fenton cast iron headers, and a Mallory dual-point distributor. This was in 1973 - I started out with 3 -1's on an Offy manifold, but once the gas crunch hit I went back to one 1 on the stock manifold and switched the gears from 4.11's to 3.55 (it was a '56 Chevy rear). It was blast to drive!