Some of the early 1980 Chevy Inline six motors had a carb that sat sideways. The carb was the same one used on Front wheel drive GM cars, so the throttle cable curved around and pulled from the side.
I think maybe in Drag Racing it might make a difference, but those guys are OCD. In the real world, I dont think the motor cares, so long as you are getting an adequate supply of clean fuel.
