Acceleration can be a factor on the way a carb is mounted. 1G of acceleration will cause the fuel to "pile-up" at the back of the carb at a 45 degree angle. More than 1G will cause the fuel to pile-up at a more severe angle.
On a drag car that leaves the starting line at 3-5 G's, the fuel can/will uncover the jets in the secondary fuel bowl of a 4 barrel carb and the engine will go dead lean.
I suggest you mount the carb with the jets toward the back of the vehicle. That way when you accelerate the fuel will pile up and cover the jets. Realistic, it really won't matter which way the carb's mounted on the average, mild street car.
Ron