I've run points, factory HEI, and Pertronix. While I have never had a problem with the Pertronix setup I was always a little concerned with ignition failure on road trips.
My favorite is the early 250-292 HEI ('75-76 vintage?) with the seperate coil. Less obnoxious in appearance than the coil-in-cap style and I recall someone posting that the seperate coil style has some performance advantage but I don't know about that.
I keep a spare set of points and a coil in the toolbox for points, a spare module and pickup coil for HEI, or a complete points distributor for a Pertronix system depending on what system I'm using. A bit paranoid I suppose but it might be tough to find Pertronix parts in a road trip failure situation.
Mostly irrelevant anymore since I can't even remember the last road trip I took in one of my old cars!