There is always the possibility of running a bellcrank if youn want to mount the carb in a diffeent orientation. But as CNC said, there's no real advantage.
Most will mount with the shafts parallel, because it makes a bit of sense for fuel distribution. But, if you're blowing through, I don't think it'll make much of a difference.
Also, good to see you over from the 67-72chevytrucks.com board.

-Sam.