I am pretty sure if you custom order flat top pistons & is close to the top of the bore,the compression ratio will be really high.
To my searches,there are no turbocharger kits readily available,ready to bolt on & go for our inlines.
The problem w/using four or 2 barrel carbs,is the the throttle shafts will leak under boost,more so w/running a used carb,throttle shaft/s most likely worn.
Part of the reason I ran Weber DCOE's was that the throttle safts are sealed & do not leak,@ least the ones I had were ball bearing throttle shafts also.
They did however leak in other areas that are not supposed to leak,,not bad,but they did.
If you can use an inclosed carb bonnet cheap,that might be a better way to go,a complete incloser.
But, you can use a standard carb bonnet.
Companies make carbs made for blow through 4 bbls,but will cost you $$$.
MBHD