I have actual experience....Mounted a 390 Holley 4 bbl both ways on a 261 Chevy.First with the primaries foward like a V8,then wirh the carb sideways and the primaries outboard.I didn't notice any difference.
I think with a central mounted carb on an inline 6,the fuel distribution is poor at part throttle no matter what the carb position.
I don't like cable linkage,too dampened,reminds me of a modern car....Used traditional rods a home made bellcrank mounted on the intake for the sideways carburetor

70 Triumph 650 cc ECTA current record holder