If you dont speed shift & side step your clutch pedal while gas pedal floored, your tranny & rear should be fine.
Might be looking into a different rear axle, for later to beef up the drive train.
I do not know what size turbine wheel is in that Turbonetics turbo, if it is a stage 5 or "P" trim that will work fine for your 250 engine. Need to find out, most likely it has a "P" trim turbine wheel.
The .63 A/R on the turbine is good, any bigger, forget about boosting much below 2800 RPM.
Don't let the someone tell you to get a .96 or larger turbine housing A/R. I can tell you right now, you will not like it for a street truck, a .84 & larger A/R will give you a lot of turbo lag.
It also depends on if you want power down low & mid range, or you just want mostly top end power.?
I have brand new Turbonetics large valve T3 wastegate assy if interested. Need to weld a couple things to be usable though.
Forgot what intake you have now?
MBHD