I once ran an Iron Duke for 60 miles on 3 cylinders. The fourth had a 1" diameter hole blown through the top of the piston.
...it blew a little smoke... Had to stop every 10 miles to fill it up with oil. The oil pump pick up kept the chunks out of the engine and the only damage was the piston. Had the heads re-worked for good measure but didn't touch the bottom end other than the cleaning out the oil pan and replacing the pick up.