DCOE's have been used on the 194/292 siamese port head/engines successfully since they were introduced in the early 1960's, so need to suspect otherwise. Hank and several others have also used them on hot street 250's as well. The DCOE's are super tuneable and not bothered by the siamese ports as you might expect. One possible issue is those intakes aren't heated, so it may pose problems in areas where that is needed.