Which engine and what will it be used for? The dyno results I've seen start a around 2,500 rpm. For higher rpm big valves, lumps, and port work make a difference on a natural aspirated engine and I suppose on a blown all out race motor.
Almost all the information and parts discussed on this and other sites I've found lean very heavily toward race & hot street applications. I'm putting together a "truck" 292 and am not planning to remove the the bosses but rather reshape then. For low rpm there seems to be adequate volume for up around 4000 rpm. Velocity at low rpm falls off with bosses removed, lumps, and big valves. Now this is for an unblown engine. If you are stuffing the cylinders I'm not sure any of it matters for a 4500 rpm limit.
