Wayne,
Sounds like you have a good plan.
I think IF you have good exhaust ports, headers, and a good exhaust, a single pattern cam can actually be better.
Here is what the DeuceCoupe Gonkulator computer said for your combo. (I used the Gonkulator to compare a to a bunch of dyno runs, most notably Tom Lowe's dyno series similar to your build).
With the Crower 204-212
torq 288 at 3600
Powr 248 at 5000
With the Comp 218-218
Torq 288 at 3800
Powr 264 at 5200
With a careful build you should indeed meet your goals.
I agree w/u on carbs, I like swap meet specials plus a rebuild.
I did a lot of carb shootouts on the clock a couple years ago with a pretty stock 250-4bbl and 292-4bbl, ~170-180hp level. The CFM didn't matter as much as whether the engine just "liked" the carb. You should be fine with a Holley 600 if its set up right. But even on those, my best 600's are back from the 1950s-60s era, not the newer "reverse idle" style.
Another carb suggestion is the Ford Autolite 4100 carb, its 440-500cfm depending on which one you get, and they fit just like a Holley. And, you can always re-sell em to the original Ford guys.
I did find though, the 390cfm and 450cfm Holleys clocked the fastest on my otherwise stock sixes. A 600 Holley should be fine for yours.
