If he uses a 250 cam in a 292, or vice versa, he'll have to use an electric pump.
Didn't think about the drive lobe for the fuel pump.
Definitely don't waste money/time with the 250 cam in a 292. An electric pump is, what, $100? Then another $25-ish for the block off plate? You can get a cam, new cam gear, valve springs and valve seals for $230. Toss in lifters for $30 and you're at $140-ish over what you're talking about spending now but you get to choose the cam and it'll all be brand new stuff.