I put a '62 261 in my '50 pickup. The issues I had were:
Throttle linkage needs to be modified. Not too hard.
Water pump needs to be shortened. I got a water pump pulley off a junkyard Ford that fit perfectly and pressed the pump shaft down and cut off the excess.
Temperature sensor:
The 235 head has a bigger hole (1/2" npt) for a temperature sensor. You can use a 3/8" flare to 1/2" npt fitting to adapt the original sending unit.
Oil pressure:
The original 216 had a max of 30 lbs oil pressure so the gauge is set up accordingly. The 235 needs a 60 lb gauge. Either get a GMC gauge or a '54 gauge and change the face.
Mounts: use the 216 bellhousing and the rear mounts will fit. The front of my 261 was already drilled for the front mount so it dropped in.
Flywheel: I wanted to keep my footstomp starter but I wanted the nice 11" clutch on the 261 so I had the 261 flywheel machined to accept a 216 ring gear. Total cost: $50.
Carburator: Use the carb off the 235, the mount is differant.
Exhaust dump. The '50 and later exhaust angles back and that matches the 235/261 just fine. The earlier straight down dump doesn't. My exhaust bolted right up.
You don't have to convert to 12 volts if you do the flywheel thing that I did.
I converted to an alternator when I went to 12 volts. I also installed a dual point distrubutor plate for a better spark.
Here are a couple of pics:
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1950 Chevy pickup with '62 261, 4 speed.