Usually, intercoolers with the inlet & exit on the same side does not flow as good.
Example:
http://www.ebay.com/itm/UNIVERSAL-FULL-A...9b73a94&vxp=mtrI have a 69 Camaro engine bay & have fit this big intercooler w/3" mandrel bent piping.
Having a full size Chevy P/U, you have nothing to worry about fitting a larger intercooler & large piping, especially w/an inline six in the engine bay..
When the air has to turn 90 degrees, it will sometimes cause a drop in boost pressure, usually 1 psi for every sharp 90 degree turn. I have not tested it myself, but what I have read this seems to be the general consensus.
Running more pipes does not mean it's worse than less pipeing.
Lay out the piping to have gentle bends & try not to use 90 degree bends if possible.
Examples of mine: Note : no use of 90 degree bends.
Look @ some books or pics on the web that will show you bad designed ones & better ones.
Example of end tanks
http://www.bimmerboost.com/showthread.php?18280-Intercooler-DesignAn air to air is the mosr simplist one to install, the compressed turbocharged air will never go below ambient temps as an air to water one can when an ice box is used to chill the water.
I run a factory air to water intecooler on my Syclone.
I see below ambient air temps because I use 100% methanol injection also.
With an air to air intercooler & methanol injection, the inlet temps will be below ambient temps also.
For simplicity, go w/an air to air.
No wiring for electric pump, electric pump, water lines/hoses, possible leaks, pump can stop working, etc, etc, etc...
MBHD