Ford V8s were essentially 'crossflow' flatheads...

They ran the exhaust ports through the water jackets from one side of the block to the other.

But valves on each side of the block? I'm sure there's been an engine or two built like that, but I'm not able to recall when or what. Back in the days of 5:1 compression ratios it wouldn't have mattered much, would it?

In the same vein, the Riley engines up to the fifties ran a camshaft and pushrods on each side of the engine to give their 'hemi' heads.