Yes, it is a direct fit on a 250 head.
Cast iron manifolds usually can take the heat of a turbo.
Unless you are really trying to get every last bit of HP out of a turbocharged engine, the cast iron manifold will work great.
The SPA manifold will bolt a turbo on directly.
http://www.ebay.com/itm/230-250-292-Chev...a1ad5a5&vxp=mtrDepending on what chassis you are putting it in, the SPA manifold is an excellent choice I.M.O.
MBHD