I think the main drawback is the S/E of the rod on the 250 engine. The pin bore usually isn't centered very well and boring it that much oversize will compromise its strength if it is off center much. The compression height is right in the range of it being something to consider if it weren't for the pin issue. I've bored hundreds of SBC rods out for full floating on the S/E to install a bushing(but still not as big as the Mopar pin), and this is basically the same thing but for use with much lighter pistons and wrist pins, so not as much inertia trying to pull the rod apart. But you often have to sort through several sets to get enough that are more equally bored on the S/E to start with.
