What is your intended use for the engine? Low rpm cruiser/tractor or a screaming race engine? Look at rod ratios: you need a LONG rod with the long stroke, or piston speeds will get too high. It would run ok at low rpms, theoretically, but could not survive higher rpms. With the long stroke, and long rods, you would need extremely short pistons. Not sure that combo exists, you may run out of cylinder height no matter what.
http://victorylibrary.com/mopar/rod-tech-c.htm
