Don't forget how much crank counterweight you will have to trim to clear the wrist pin at BDC. I turned my crank weights round as far as I could, then "pendulum" cut them some more to clear 5.7 rods. And mine is destroked to 4.062 as well. I used this same crank for three builds. First two builds were 5.7 250 rods and 383 small chevy pistons at 4 inch bore. Last and current build is 6 inch rods and custom pistons, same crank. I've run all three hard street duty for fun. Not racing.

6 inch rods means you won't have to trim as much in addition to improved geometry as pointed out above.